Multi-Center CLEAN AIR Randomized Controlled Trial in COPD

Clean Air is a multi-center, randomized trial that aims to enroll 770 former smokers with Chronic Obstructive Pulmonary Disease (COPD) throughout the United States. This research is being conducted to help understand if air cleaners can be an effective tool to improve COPD symptoms and decrease rescue medication use by purifying indoor air. This study is funded by the National Heart, Lung and Blood Institute (NHLBI).

Study participation lasts one year. Participants will receive two air cleaners to run constantly in the home for one year. Some air cleaners will have HEPA filters, and some will not. At the end of the study, everyone will receive working air cleaners with filters. Monitors will capture the indoor air quality and rescue medication use.

There is a single in-person baseline clinic visit and five or more remote follow-up calls. Study activities include:
  • Demographics and medical history collection
  • Physical exam for weight, weight, blood pressure, pulse, and respiratory rate
  • Questionnaire administration to evaluate health and environmental factors
  • Spirometry to diagnose COPD and measure lung function
  • Blood and urine collection
  • Medical record collection, if hospitalized
Compensation will be provided for time and electricity.

Videos for Participants


   NO2 Training
   Air Nicotine Training
   Purple Air Training